Which of the following statements is FALSE regarding the equivalencies of HLA alleles?

Study for the Certified Histocompatibility Specialist Test. Prepare with flashcards and multiple choice questions, each question has hints and explanations. Get ready for your exam!

The assertion that B1501 is equivalent to B77 is false because the HLA nomenclature specifies that B1501 is a specific allele of the B locus, while B77 corresponds to a different allele group that encompasses multiple HLA alleles. In HLA terminology, the asterisk (*) notation indicates a specific allele, while the number used without the asterisk represents a serological specificity, which can group several alleles under one designation.

In the context of this question, the other statements accurately reflect the equivalencies. B3501 is indeed equivalent to the serotype B35, indicating a well-defined relationship between the allele and its corresponding serological type. Similarly, B1522 is correctly identified as equivalent to B3543; they represent different notations of the same allele. Lastly, B5002 corresponds appropriately to B45, indicating that the alleles fit into established equivalencies within the HLA system.

Understanding these relationships is crucial for accurate identification and interpretation of HLA typing in clinical practice and transplantation immunology.

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