Certified Histocompatibility Specialist Practice Test

The best matching donor for a bone marrow transplant is determined primarily by the HLA (human leukocyte antigen) typing of the donor and recipient. HLA compatibility is crucial for minimizing the risk of transplant rejection and achieving a successful graft.

In the case of the patient with the genotype A1, A11, B62, B64, DRB1*0103, DRB1*1501, the ideal donor would match as many of the HLA alleles as possible. The answer that aligns most closely with the patient’s genetic profile is the one that provides exact matches for the critical loci, specifically the class I alleles (A and B) and the class II alleles (DRB1).

The correct answer includes A1 and A11, which match exactly with the patient's A alleles. It also has DRB1*0103, matching perfectly with one of the patient’s DRB1 alleles. While it includes other B alleles (B*1401 and B*15) that are not exact matches to B62 and B64, these may still be acceptable depending on the level of compatibility needed and the specific circumstances of the transplant.

This answer represents the best overall compatibility based on matching critical alleles