Peptides that bind to MHC class I molecules differ from those that bind to MHC class II molecules in all except which of the following ways?

Peptides that bind to MHC class I molecules are generally shorter, typically composed of 8-11 amino acids, which enables them to fit into the relatively closed binding groove of the MHC class I molecules. In contrast, MHC class II molecules accommodate longer peptides, usually ranging from 13 to 25 amino acids, allowing them to extend outside the binding groove. This difference in peptide length is significant and thus supports the assertion that they are shorter.

Furthermore, the processing of peptides for MHC class I and MHC class II molecules involves distinct pathways and proteolytic enzymes. MHC class I molecules present intracellular antigens processed by proteasomes, while MHC class II molecules typically present extracellular antigens processed after being internalized into vesicles and degraded by enzymes specific to those compartments.

While MHC class I molecules primarily interact with CD8+ T cells, and MHC class II molecules with CD4+ T cells, these specificities are fundamentally tied to the structural differences in the MHC molecules themselves.

The characteristic that peptides anchor in the middle rather than the end is not accurate, as both MHC class I and class II molecules have different anchoring mechanisms: MHC class I anchors its peptides typically at the ends,