Linkage disequilibrium between HLA loci is correlated with what factor?

Linkage disequilibrium between HLA loci is largely influenced by the physical distance between these loci on chromosome 6. When loci are located close to each other on the same chromosome, they tend to be inherited together more frequently than would be expected by chance. This is due to the reduced likelihood of recombination events occurring between closely spaced loci during meiosis. Consequently, polymorphisms at adjacent loci are often found in specific combinations, leading to linkage disequilibrium.

On the other hand, the order of discovery of the loci does not have a direct impact on their linkage disequilibrium. Similarly, ABO blood types are a different set of polymorphisms and do not correlate with the linkage disequilibrium among the HLA genes. Sex may influence certain aspects of genetics, but it is not a factor that specifically correlates with linkage disequilibrium among HLA loci. Hence, the correlation is most accurately associated with the physical distance between the loci on chromosome 6.