In a sample typed as DRB1*010202, DRB1*0301, DQB1*0201, DQB1*0302, which statement could not explain the results?

Study for the Certified Histocompatibility Specialist Test. Prepare with flashcards and multiple choice questions, each question has hints and explanations. Get ready for your exam!

The statement that could not explain the results is the one suggesting that in the presence of DRB10301, the DRB10102 may be linked to DQB1*0302. This is because the linkage disequilibria observed in HLA typings are influenced by the population's genetics and the overall haplotype structure. If you observe a specific allele of DRB1 and a specific allele of DQB1, they are often observed together in certain populations due to common ancestry or shared genetic backgrounds.

Since DRB10102 is typed along with DRB10301, it implies that these two alleles are separate and typically do not link with DQB10302 in the context of common allelic associations. The assumption that DRB10102 could directly associate with DQB1*0302 in this scenario does not align with established linkage patterns observed in most populations.

The other statements are valid because they discuss possibilities that could be true given different population structures. For instance, isolated populations may indeed exhibit unique patterns of linkage disequilibria, and exceptions to common linkages occur, such that certain allele combinations may not always conform to expected patterns. Additionally, because DR

Subscribe

Get the latest from Examzify

You can unsubscribe at any time. Read our privacy policy