How does the resolution of SBT results compare to PCR-SSP results?

The resolution of SBT (Sequence-Based Typing) results compared to PCR-SSP (Polymerase Chain Reaction - Sequence Specific Primers) results can vary depending on the specific alleles being tested. SBT typically provides higher resolution typing because it sequences specific regions of the genes to identify the specific nucleotide variations in the alleles. This allows for differentiation among closely related alleles that might be indistinguishable by PCR-SSP, which uses primers to amplify specific alleles but may not capture the full complexity of the HLA gene variations.

However, the resolution can indeed depend on the alleles in question. Some alleles may have minimal variations that PCR-SSP can accurately identify, while others may have significant differences that only SBT can resolve. Therefore, the correct response highlights the importance of the specific contexts and alleles involved in determining the resolution capabilities of both methods.