Based on provided data, what is the most probable haplotype for Patient A?

Study for the Certified Histocompatibility Specialist Test. Prepare with flashcards and multiple choice questions, each question has hints and explanations. Get ready for your exam!

To determine the most probable haplotype for Patient A, one must consider the association of specific HLA alleles with certain diseases, population genetics, and historical haplotype data. HLA haplotypes are often studied in relation to their frequency in different populations and their linkage disequilibrium.

The haplotype A29, B7, DR15 is of particular interest as it is commonly seen in certain populations and has specific associations with autoimmune diseases and transplant compatibility. A29 is known for its relatively high prevalence in certain ethnic groups, and B7 and DR15 are frequently found together with A29. This combination enhances the likelihood of biological compatibility in transplant situations.

In contrast, other haplotypes presented might not have the same level of association or probability based on the underlying population data. For instance, A11 may not have the same historical prevalence as A29 in the patient population under assessment. Similarly, variations in B and DR alleles influence their overall compatibility with Patient A's immunological profile.

The choice of A29, B7, DR15 reflects established data indicating a favorable match and compatibility for the patient in terms of transplantation prospects or disease association. Therefore, when analyzing the haplotypes in the context of patient data,

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