A patient with an anti-HLA-Bw4 antibody would be most likely to have a positive T cell crossmatch with which of the following donors?

A positive T cell crossmatch occurs when the recipient's antibodies react with donor T cells, indicating a potential for graft rejection. In the context of anti-HLA-Bw4 antibodies, it is crucial to understand that these antibodies specifically target the Bw4 epitope, which is a part of the HLA-B allele.

The correct choice, featuring A11, A29, B38, B62, DR4, and DR7, is likely to correspond to a donor with one or more HLA-B alleles that express the Bw4 epitope. The presence of anti-HLA-Bw4 antibodies in the patient indicates a pre-existing immunization against this particular epitope. Therefore, donors with HLA-B alleles that also display the Bw4 phenotype will provoke a positive crossmatch due to the recognition of these antigens by the patient’s antibodies.

In this scenario, the other options present combinations of HLA types that do not prominently feature the Bw4-associated alleles, making them less likely to cause a positive crossmatch. In contrast, the selected donor option has alleles likely to exhibit the Bw4 epitope, thus demonstrating an inherent compatibility issue that could lead to a positive T cell crossmatch with the