A patient with an anti-HLA-B8 CREG antibody might be expected to have positive T cell crossmatches with all of the following donors except?

The presence of anti-HLA-B8 CREG antibodies indicates that the patient has developed antibodies against a specific subset of HLA molecules associated with the B8 haplotype. When considering crossmatching with potential donors, it's essential to identify which HLA types are compatible and which are likely to elicit an immune response.

In this case, the answer indicates that option A should not yield positive T cell crossmatches. The donors listed in this option include various HLA types: A1, A3, B8, B35, DR4, and DR17. Notably, the presence of B8 among these donor types is significant, as it directly correlates with the patient's antigens against which they have developed antibodies. Since the patient has anti-HLA-B8 antibodies, crossmatching with any donor expressing B8 is likely to result in a positive match due to the direct recognition of these antibodies against the B8 antigen.

On the other hand, the other options contain HLA types that do not include B8, potentially leading to negative crossmatches. For example, the second option features only HLA types that fall outside the B8 CREG, thus reducing the likelihood that the patient’s antibodies will react to these donors. The same